Welcome Guest
Sign In
Register
Products
Popular Categories
Antibody Search
ELISA Kit Search
Biomolecules
Flow Cytometers
Thermal Cyclers
Microscopes
Transfection Reagents
Featured Products
New Products
Articles
Resources
eBooks
Bench Tips
Tech Insights
Editorial Articles
News
Product Reviews
Future Lab
Multimedia
Biocompare Webinars
Immunotherapy
Reproducibility
Transformative Technologies
Podcasts
Tech Talks
Bench Tip Videos
All Videos and Webinars
Life Science Webinars
Write a Review
Antibodies
Kits/Reagents
Equipment
Services
Resources
Promotions
Events
AACR SPOTLIGHT
Register
Sign In
Biocompare
Products
Protein Biochemistry
Chemicals and Reagents
C59, Wnt Antagonist, Wnt signaling pathway inhibitor
C59, Wnt Antagonist, Wnt signaling pathway inhibitor from Abcam
(1)
Write a review
Citations:
(7)
Supplier Page
Supplier Page from
Abcam for
C59, Wnt Antagonist, Wnt signaling pathway inhibitor
Description
Potent, cell-permeable Wnt signaling pathway inhibitor
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
C59, Wnt Antagonist, Wnt signaling pathway inhibitor
Company
Abcam
Price
Supplier Page
View Company Product Page
Catalog Number
ab142216
Quantity
1 MG, 5 MG
Purity
0.97
Type
inhibitor
Add to Compare List
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB2 0AX
United Kingdom
Phone
: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600
Company Profile
Website:
http://www.abcam.com
Citations (7)
(1)
SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseases
Nature Communications
June 8, 2023
Fabrice Gonnot, Laura Boulogne, Camille Brun, Maya Dia, Yves Gouriou, Gabriel Bidaux, Christophe Chouabe, Claire Crola Da Silva, Sylvie Ducreux, Bruno Pillot,
et al.
for three days, renewed after 2 days. hiPSCs are then treated with 2 μM
C59-Wnt antagonist
(
Abcam
,
Ab142216
) in RPMI 1640 medium supplemented with B27 minus insulin. After five days, cells are switch in
RPMI 1640 medium
(2)
RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
eLife
October 27, 2021
Radaszkiewicz T, Nosková M, Gömöryová K, Vondálová Blanářová O, Radaszkiewicz KA, Picková M, Víchová R, Gybeľ T, Kaiser K, Demková L,
et al
.
inhibition of endogenous Wnt ligands, cells were treated with the 0.5 μM Porcupine
inhibitors
C-59 (
ab142216
,
Abcam
) or 1 μM LGK-974 (1241454, PeproTech). The time points and doses have been chosen based on the
(3)
Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments
ACS Pharmacology & Translational Science
June 11, 2021
Paweł Kozielewicz, Rawan Shekhani, Stefanie Moser, Carl-Fredrik Bowin, Janine Wesslowski, Gary Davidson, Gunnar Schulte
Molecular
weights
of the WNTs were as per supplier’s datasheets. Porcupine
inhibitor
C59 was from
Abcam
(#
ab142216
, Cambridge, UK).57 C59 was dissolved in DMSO at 5 mM and stored at −20 °C. The serial dilutions of WNTs
(4)
Reduced WNT5A signaling in melanoma cells favors an amoeboid mode of invasion
Molecular Oncology
May 15, 2021
Njainday Pulo Jobe, Lisa Åsberg, Tommy Andersson
Munich, Germany, Cat#
S1267
) or DMSO for the final 24 h of siRNA
transfection
. For C59 (
Abcam
, Cat#:
ab142216
) treatment, HTB63 and WM852 cells were incubated with 1 μm C59 or vehicle (DMSO) control in either collagen
(5)
Differentiation of Human Cardiac Atrial Appendage Stem Cells into Adult Cardiomyocytes: A Role for the Wnt Pathway?
International Journal of Molecular Sciences
May 30, 2020
Leen Willems, Annick Daniëls, Yanick Fanton, Loes Linsen, Lize Evens, Virginie Bito, Jeroen Declercq, Jean-Luc Rummens, Karen Hensen, Marc Hendrikx
BC, Canada), IWP2 (4 and 20 µM;
Sigma Aldrich
;
I0536
, St. Louis, MI, USA), C59 (1 and 5 µM;
Abcam
;
ab142216
, Cambridge, UK),
XAV939
(2 and 10 µM;
Sigma Aldrich
;
X3004
, St. Louis, MI, USA), and IWR1-endo (4 and
(6)
Structural insight into small molecule action on Frizzleds
Nature communications
January 21, 2020
Kozielewicz P, Turku A, Bowin CF, Petersen J, Valnohova J, Cañizal MCA, Ono Y, Inoue A, Hoffmann C, Schulte G.
cell exposure. C59 (2-[4-(2-methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide;
Abcam
#
ab142216
; stored as 5 mM solution in aliquots in dimethyl sulfoxide (DMSO; at −20 °C) was used to
inhibit
porcupine
(7)
CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model
International Journal of Molecular Sciences
September 29, 2016
Weiwei Lu, Jia Shi, Jinming Zhang, Zhengtao Lv, Fengjing Guo, Hui Huang, Wentao Zhu, Anmin Chen
aggrecan neo-epitope 374ARGSV (
ab3773
), PNCA (
ab29
), SB202190 (
ab120638
), U-0126 (
ab120241
), and C59 (
ab142216
) were purchased from
Abcam
(Cambridge, UK). Antibodies for ERK (#9102), phospho-ERK (#4377), JNK (#9258),
<<
<
>
>>
Reviews
Write a Review
(1)
6/25/2019
C59 Is an Effective Wnt Antagonist Useful for Wnt-Based Experiments (Abcam)
Ab G
C59 can be dissolved in DMSO for treatment of human breast cancer cells to determine dependency on Wnt signaling. This can also be a viable option as a positive control for comparison with other ...
Read Review
<<
<
>
>>
C59, Wnt Antagonist, Wnt signaling pathway inhibitor from Abcam
Supplier Page
View Company Product Page
Product Specs
Company Info
Citations
Reviews
Back To Top